• Policy
  • Alopecia
  • Aderans Research & Development
  • Research Partners
  • Endowment Department・Joint Research
  • Research Partner Companies

Aderans Research & Development

We aim at regenerating hair follicles which have stopped their activities from the viewpoint of nursing.

We aim at regenerating hair follicles which have stopped their activities from the viewpoint of nursing.

There are a perspective and motivation specific to nursing which exists for cuddling up to patients.
You have to understand alopecia not only as a disease related to hair but also the whole scalp.
That is why normalization of hair follicles is more and more emphasized.

Hair is also important for healthy skin

Could you tell me what made you decide to get involved in research on hair regeneration?

I studied the Zootechnical Science, Department of Agriculture at graduate school. I was engaged in a research on application of somatic cell nuclear transfer technology used for the world’s first cloned sheep “Dolly” to chicken when I was a postgraduate student, when I entered into basic medical research. I began to learn suffering in patients with spinal cord injury. As patients with spinal cord injury are confined to a wheelchair, they develop bed sores. Thus, I formed a connection with department of nursing. This is why I started the research on hair regeneration.
Initially, I was involved in research on skin itself. The skin has a barrier function which prevents foreign bodies from entering the body or blocks the escape of water and electrolytes. When barrier function is reduced with aging or by disease, they may suffer from itchy or sore skin or wound or infection.
As I continued the research, I recognized that the inner pore has a weaker barrier function. If you have body hair, you get a situation like pores being covered by a cap, while if you have no body hair, your pores are completely exposed to outside air. It is not preferable for healthy skin. So, I realized “hair follicles play an important role”.
At the same time, I thought that it would be unable to explain phenomena occurred in skin without looking at comprehensively the whole scalp including epidermal appendages such as hair follicles, sebaceous and sweat glands.

Could you describe it more specifically? How did you notice it?

long time is vulnerable to pressure sores. When investigating its cause, I began to find that it was caused by moist conditions from wearing diapers. If moist conditions in the diaper continue, skin becomes “wrinkly”. In that case, high molecular weight proteins can penetrate into the skin although they cannot do so under normal conditions. The skin becomes vulnerable by these proteins themselves or inflammatory response to the effects by the proteins. When scrutinizing where such phenomenon tends to occur, I found that it occurred in hair follicles. Hair follicles are the weakest parts of skin barrier function. As for the scalp with rich hair, pores mean a lot compared with the other parts of skin. Then, I felt necessity of focusing on the scalp when proceeding with research on skin care. I believe doing so will materialize better skin care in patients.

Hair lost by burns may regenerate

Which stage are you in now?

Stimulated by encountering nursing, I began to give serious consideration about bed sores and thus I wished to regenerate hair lost caused by wound like pressure sores. As I was previously engaged in research on regenerative medicine, I think two subjects of my research agreed. This is really a surprise or joy to me.
When severe pressure sores or burns heal, the affected areas become scarred from which epidermal appendages including hair follicles are lost. The scar tissue may have recurrent pressure sores or become itchy or painful. My ultimate goal is to find a way of regenerating hair follicles or epidermal appendages in the scarred tissue to return to as they used to be as much as possible.
We discovered AHL by chance while we did research on pressure sores. We have so far demonstrated that AHL has an effect of activating hair follicles which are inactive and promoting hair growth. Moreover, we found that the substance was capable of reducing markedly oxidant stress in skin. In short, we expect that AHL may be a promising drug which contributes to improvement of scalp conditions and facilitation of hair growth.
Now, we get to the point where we begin to elucidate a big picture view of AHL’s impact on the scalp by demonstrating these effects one by one.

Does this hold true for androgenic alopecia?

I believe there is any possibility. We also expect that AHL can be applied for the treatment of various types of alopecia including age-related alopecia which progresses with aging regardless of gender, alopecia areata caused by immune dysregulation and drug-induced alopecia which gives damage on the whole scalp by anticancer drugs as well as androgenic alopecia.
A large number of research has been so far conducted but those made commercially available are only for androgenic alopecia. We aim to put an AHL product which is effective for a variety of alopecia into practical use. I believe it would be better if nurses can use it.

Interviewer/writer: Takeshi Maeya Photographer: Kuninobu Akutsu

History of development, products and services based on research of Aderans
Return to the Top Page